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OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil.
Clin Pharmacol Ther. 2019 Jan;105(1):190-200. doi: 10.1002/cpt.1128. Epub 2018 Aug 1.
Clin Pharmacol Ther. 2019.
PMID: 29882324
Clinical Trial.
The prototypic pharmacogenetic drug debrisoquine is a substrate of the genetically polymorphic organic cation transporter OCT1.
Saadatmand AR, Tadjerpisheh S, Brockmöller J, Tzvetkov MV.
Saadatmand AR, et al. Among authors: tadjerpisheh s.
Biochem Pharmacol. 2012 May 15;83(10):1427-34. doi: 10.1016/j.bcp.2012.01.032. Epub 2012 Feb 10.
Biochem Pharmacol. 2012.
PMID: 22342776
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The poorly membrane permeable antipsychotic drugs amisulpride and sulpiride are substrates of the organic cation transporters from the SLC22 family.
Dos Santos Pereira JN, Tadjerpisheh S, Abu Abed M, Saadatmand AR, Weksler B, Romero IA, Couraud PO, Brockmöller J, Tzvetkov MV.
Dos Santos Pereira JN, et al. Among authors: tadjerpisheh s.
AAPS J. 2014 Nov;16(6):1247-58. doi: 10.1208/s12248-014-9649-9. Epub 2014 Aug 26.
AAPS J. 2014.
PMID: 25155823
Free PMC article.
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